METHODS FOR PREVENTING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN

Title:

METHODS FOR PREVENTING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN

Document Type and Number:

Japanese Patent JP2009102413

Kind Code:

A

Abstract:

To provide a method for administering a glucocorticoid receptor antagonist to a patient receiving AP regimen for a long term.

The present invention generally pertains to the field of psychiatry. In particular, the present invention pertains to the discovery that agents inhibiting the binding of cortisol to its receptors can be used in methods for preventing antipsychotic-induced weight gain. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for preventing AP-induced weight gain in a human including a glucocorticoid receptor antagonist and instructional material teaching the adaptation syndrome, dosage and schedule of administration of the glucocorticoid receptor antagonist.

Inventors:

BELANOFF JOSEPH K
SCHATZBERG ALAN F

Application Number:

JP2009023156A

Publication Date:

May 14, 2009

Filing Date:

February 03, 2009

Export Citation:

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Assignee:

CORCEPT THERAPEUTICS INC

International Classes:

A61K45/00; A61K45/06; A61K31/00; A61K31/454; A61K31/519; A61K31/5513; A61K31/5517; A61K31/554; A61K31/567; A61K31/569; A61K31/575; A61P3/04; A61P25/18; A61P43/00; C07J43/00

Foreign References:

WO1999017779A1	1999-04-15
WO2000071106A2	2000-11-30

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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