Title:
治療薬に対する細胞の応答を予測するための方法およびシステム
Document Type and Number:
Japanese Patent JP2012500008
Kind Code:
A
Abstract:
The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.
Inventors:
Shoval bargit
Harms Brian
Gibbons Francis David
Fitzgerald Jonathan Basil
On Sam Matthew David
Nielsen Wurrick
Kubasek William
Harms Brian
Gibbons Francis David
Fitzgerald Jonathan Basil
On Sam Matthew David
Nielsen Wurrick
Kubasek William
Application Number:
JP2011523216A
Publication Date:
January 05, 2012
Filing Date:
August 17, 2009
Export Citation:
Assignee:
Merrimack Pharmaceuticals Inc.
International Classes:
C12Q1/68; A61K31/5377; A61K39/395; A61P35/00; C07K16/18; C12N15/02; C12P21/08; G01N33/68
Domestic Patent References:
| JP2005504044A | 2005-02-10 | |||
| JP2006523314A | 2006-10-12 | |||
| JP2010518820A | 2010-06-03 | |||
| JP2007506088A | 2007-03-15 | |||
| JP2008523017A | 2008-07-03 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto