Title:
METHODS FOR TREATING OR PREVENTING INFLUENZA VIRUS INFECTION BY ADMINISTERING SERINE PROTEASE INHIBITOR
Document Type and Number:
Japanese Patent JP2018048169
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide treatment agents which target the proteolytic activity of type II transmembrane serine protease (TTSP) in the treatment and/or prevention of influenza virus infection.SOLUTION: The present invention relates to a pharmaceutical composition containing a TTSP inhibitor for use in preventing or reducing the accumulation of influenza-infected alveolar macrophages, influenza-infected neutrophils and/or influenza-infected epithelial cells in the lungs of a subject that has been exposed to or infected with influenza virus. The TTSP inhibitor is a transmembrane protease serine S1 member 2 (TMPRSS2) inhibitor. TTSP inhibitor is a fully human antibody or an antigen binding fragment thereof which binds TMPRSS2 specifically and inhibits its proteolytic activity. The antibody or the antigen binding fragment thereof inhibits the protease activity of TMPRSS2, but does not substantially inhibit the protease activity of any other kind of TTSP.SELECTED DRAWING: None
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Inventors:
LISA A PURCELL NGAMBO
Application Number:
JP2017203146A
Publication Date:
March 29, 2018
Filing Date:
October 20, 2017
Export Citation:
Assignee:
REGENERON PHARMA
International Classes:
A61K39/395; A61K31/13; A61K31/137; A61K31/215; A61K31/351; A61K39/145; A61K45/00; A61P31/16; A61P43/00
Domestic Patent References:
| JP2008526857A | 2008-07-24 | |||
| JP2015507076A | 2015-03-05 |
Other References:
DRUG DELIVERY SYSTEM, vol. Vol.28-5, JPN6018022591, 2014, pages 430 - 438
JOURNAL OF VIROLOGY, vol. 84, no. 11, JPN6018022590, 2010, pages 5605 - 5614
JOURNAL OF VIROLOGY, vol. 84, no. 11, JPN6018022590, 2010, pages 5605 - 5614
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi