Title:
修飾された生体関連物質、その製造方法および中間体
Document Type and Number:
Japanese Patent JP4412461
Kind Code:
B2
Abstract:
Provided is a polyalkylene glycol derivative substantially containing no secondary hydroxyl group and being represented by the following formula (p):
wherein each R is a hydrocarbon group having 1 to 24 carbon atoms, the groups represented by R being the same or different from each other in one molecule, OA 1 and each OA 2 are oxyalkylene groups having 2 to 4 carbon atoms, the groups represented by OA 2 being the same or different from each other in one molecule, and n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000. The above derivative may be prepared by debenzylating a compound of the formula (4):
wherein R, OA 1 , OA 2 , n and m are as defined above,
the polyalkylene glycol derivative of formula (p) satisfying the following parameter: Hrd / Mp × 1000000 3
wherein Mp is the molecular weight corresponding to the peak top obtained from gel permeation chromatography of the derivative of formula (p), and Hrd is the ratio of hydroxyl group residue contained in the alkyl group R at the polyoxyalkylene chain terminal end at the 2- and 3-positions of the compound of the formula (4).
Inventors:
Kenichiro Nakamoto
Shunsuke Ohashi
Yuji Yamamoto
Kenji Sakagami
Chika Ito
Toru Yasukawachi
Shunsuke Ohashi
Yuji Yamamoto
Kenji Sakagami
Chika Ito
Toru Yasukawachi
Application Number:
JP2003388886A
Publication Date:
February 10, 2010
Filing Date:
November 19, 2003
Export Citation:
Assignee:
NOF CORPORATION
International Classes:
A61K47/48; C08G65/329; A61P43/00; C07C43/13; C07C43/164; C07K14/47; C08G65/26; C08G65/28; C08G85/00
Domestic Patent References:
| JP8059818A | ||||
| JP11228685A | ||||
| JP2000001541A | ||||
| JP11171988A | ||||
| JP4209627A | ||||
| JP2196827A | ||||
| JP2003113241A |
Foreign References:
| WO2002060978A1 |
Attorney, Agent or Firm:
Masumi Hosoda
Juno Aoki
Juno Aoki