Title:
修飾されたヒト腫瘍壊死因子受容体−１ポリペプチドまたはその断片及びその製造方法
Document Type and Number:
Japanese Patent JP5746191
Kind Code:
B2
Abstract:
The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.
Inventors:
Kim, Seung Wook
Jun, Sung Soo
Park, Sun Cook
Kim, Song Yang
Kim, Yoon Sung
Jeon, Jecap
Kim, Hana
Song, Yong Jun
Jun, Sung Soo
Park, Sun Cook
Kim, Song Yang
Kim, Yoon Sung
Jeon, Jecap
Kim, Hana
Song, Yong Jun
Application Number:
JP2012534123A
Publication Date:
July 08, 2015
Filing Date:
October 19, 2010
Export Citation:
Assignee:
HanAll Biopharma Co., Ltd.
International Classes:
C12N15/09; A61K38/00; A61P1/04; A61P1/14; A61P1/18; A61P3/02; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/16; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P25/08; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07K14/715; C12N1/21; C12P21/02
Domestic Patent References:
| JP2002220342A | ||||
| JP2002514048A | ||||
| JP2008511300A |
Foreign References:
| WO2004022747A1 |
Other References:
J.Med.Chem.,1999 Jul 1,42(13),p.2295-314
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
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