Title:
ＣＤ２８結合のための一価組成物および使用方法
Document Type and Number:
Japanese Patent JP5876134
Kind Code:
B2
Abstract:
Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
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Inventors:
Murray McKinnon
Stephen G. Nadler
Susan Jay Thatchard
Brendan Classon
Steve Holmes
Olga Ignatovic
Christopher Plummer
Steve Grant
Stephen G. Nadler
Susan Jay Thatchard
Brendan Classon
Steve Holmes
Olga Ignatovic
Christopher Plummer
Steve Grant
Application Number:
JP2014261305A
Publication Date:
March 02, 2016
Filing Date:
December 24, 2014
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07K16/28; A61K39/395; A61K45/00; A61P1/04; A61P3/10; A61P9/10; A61P17/00; A61P17/06; A61P25/00; A61P29/00; A61P37/02; A61P37/06; C07K16/46; C12N15/09
Domestic Patent References:
| JP2004516034A |
Foreign References:
| WO2008071447A1 | ||||
| US20080095774 | ||||
| US20020006403 |
Other References:
TRANSPLANTATION,米国,WILLIAMS AND WILKINS,2008年 4月15日,V85 N7,P1051-1055
BLOOD,米国,AMERICAN SOCIETY OF HEMATOLOGY,2003年 7月15日,V102 N2,P564-570
JOURNAL OF IMMUNOLOGY,2007年12月,V179 N12,P8164-8171
BLOOD,米国,AMERICAN SOCIETY OF HEMATOLOGY,2003年 7月15日,V102 N2,P564-570
JOURNAL OF IMMUNOLOGY,2007年12月,V179 N12,P8164-8171
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura