Title:
MOTILIN ANTAGONIST
Document Type and Number:
Japanese Patent JP3449766
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound or its salt which comprises phenylalanine, lysine, tyrosine derivative and β-alanine and has a possibility of a therapeutic agent for hypersensitive intestine syndrome as an antagonist of motilin, one of digestive tract hormones.
CONSTITUTION: A novel compound of the formula, a linear peptide of 22 amino acids, as an antagonist of motilin, one of digestive tract hormones, which is extracted from swine duodenum. The peptide is obtained by linking amino- protected β-alanine, t-butyltyrosine, lysine and phenylalanine to the carrier in order according to the solid phase method of peptide synthesis to form the protected peptide chain, then treated with trifluoroacetic acid to effect deprotection and elimination of the peptide from the carrier. Finally, the peptide is cyclized intramolecularly in a solvent and purified through the HPL chromatography.
Inventors:
Eigoro Murayama
Masayuki Haramura
Masayuki Haramura
Application Number:
JP33872893A
Publication Date:
September 22, 2003
Filing Date:
November 19, 1993
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07D255/02; A61K38/22; A61P1/00; C07K5/023; (IPC1-7): C07K5/023
Other References:
【文献】Am J Physiol,1989年,257,G470-G474
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