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Title:
MRSA-ACTIVE 2-PHENYL-CARBAPENEM
Document Type and Number:
Japanese Patent JPH07278147
Kind Code:
A
Abstract:

PURPOSE: To provide new compounds which are active against Gram-positive bacteria and Gram-negative bacteria and useful as not only antibacterial agents but also additive to animal feeding stuff and food preservatives and disinfectants or the like.

CONSTITUTION: The objective MRSA-active 2-phenyl-carbapenems are represented by formula I [wherein R is H or CH3; R2 is (R)-CH3CH(OH)-, or (R)-CH3CH(F)-; Ra1 and Ra3 are each a halogen, -SCH3 or the like; M is a cation or an ester; provided that when R is H, R2 is not (R)-CH3CH(OH)] and include, e.g. sodium (5R,6S)-2-[3-bromphenyl]-6-[(1R)-hydroxyethyl]-carbapen-2-em-3- carboxylate. The exemplified compound can be derived, e.g. from an ylide ketone of formula III which have been obtained by dropping a Grignard solution to (3S,4R)-1-{[(allyloxy)carbonyl](tri-phenylphospholanylidene)methyl}-3-[(1 R)-1-(allyloxycarbonyloxy)ethyl]-4-{(1R)-2'-[(pyridylthio)car bonyl]methyl}azetidin-2-one.


Inventors:
FURANKU DAININNO
RABINDORA ENU GATSUHIKONDA
Application Number:
JP8704195A
Publication Date:
October 24, 1995
Filing Date:
April 12, 1995
Export Citation:
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Assignee:
MERCK & CO INC
International Classes:
A61K31/397; A61K31/40; A61K31/44; A61K31/695; A61P31/04; A61P43/00; A61K31/195; C07D477/00; C07D477/14; C07F7/18; (IPC1-7): C07D477/00; C07F7/18
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)



 
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