Title:
MYOCARDIAL REGENERATION PROMOTING COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION, AND THEIR USE
Document Type and Number:
Japanese Patent JP2020164528
Kind Code:
A
Abstract:
To provide a novel compound that can improve regeneration and repair of myocardial cells, and thereby provide a non-invasive, therapeutic method for myocardial infarction.SOLUTION: The present invention discloses a novel 3-aryl-2-propen-1-one series derivative and a synthesis processes thereof. Besides, the present invention also discloses use of a pharmaceutical composition and a series derivative thereof for promoting myocardial regeneration.SELECTED DRAWING: Figure 2
Inventors:
LEE LAIN-TZE
TSAI HUI-PING
HUANG SHU-FEN
RIN YI-WEN
HUANG BI-CAN
WU YING-YING
CHEN MEI-HWAI
XU LI-XIE
TSAI HUI-PING
HUANG SHU-FEN
RIN YI-WEN
HUANG BI-CAN
WU YING-YING
CHEN MEI-HWAI
XU LI-XIE
Application Number:
JP2020079842A
Publication Date:
October 08, 2020
Filing Date:
April 28, 2020
Export Citation:
Assignee:
GENHEALTH PHARMA
International Classes:
A61K31/167; A61K31/19; A61K31/196; A61K31/216; A61K31/222; A61K31/225; A61K31/235; A61K31/27; A61K31/36; A61K31/381; A61K31/4025; A61K31/427; A61K31/4402; A61K31/4406; A61K31/4409; A61P9/00; A61P9/04
Domestic Patent References:
| JP2013028642A | 2013-02-07 | |||
| JP2007262050A | 2007-10-11 | |||
| JP2002508323A | 2002-03-19 | |||
| JP2000053766A | 2000-02-22 | |||
| JPH10502338A | 1998-03-03 | |||
| JP2009537462A | 2009-10-29 |
Foreign References:
| WO2017197637A1 | 2017-11-23 |
Other References:
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PHYTOTHER.RES., vol. 30, no. 7, JPN6021012355, 2016, pages 1146 - 1155, ISSN: 0004965247
HIXSON,J.L. ET AL.: "Hydroxycinnamoyl Glucose and Tartrate Esters and Their Role in the Formation of Ethylphenols in Wine", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 64, no. 49, JPN6020003206, 2016, pages 9401 - 9411, XP055623577, ISSN: 0004965252, DOI: 10.1021/acs.jafc.6b04074
FOOD AND CHEMICAL TOXICOLOGY, vol. Vol.60, Page.348-354, JPN6021044823, 2013, ISSN: 0004965248
BIOMEDICINE & PHARMACOTHERAPY, vol. Vol.85, Page.582-591, JPN6021044822, 2017, ISSN: 0004965249
FOOD RESEARCH INTERNATIONAL, vol. Vol.45, No.1, Page.155-160, JPN6021044820, 2012, ISSN: 0004965250
PHYTOTHERAPY RESEARCH, vol. Vol.32, pp.1983-1991, JPN6023000388, 2018, ISSN: 0004965246
STOUT,M.D. ET AL.: "Ester derivatives of 2,6-bis(1-pyrrolidinylmethyl)-4-benzamidophenol as short-acting antiarrhythmic", JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 8, JPN6020003208, 1989, pages 1910 - 1913, ISSN: 0004793085
SURYANARAYANA,B.N. ET AL.: "An approach to "escape from flatland": chemo-enzymatic synthesis and biological profiling of a libra", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 15, JPN6020003199, 2016, pages 3821 - 3837, XP055580986, ISSN: 0004793086, DOI: 10.1039/C5OB02539G
OGAWA,S.: "The Application Of the Perkin reaction to phenolic aldehydes", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. Vol.2, 20-6, JPN6020003203, 1927, pages 20 - 26, ISSN: 0004793087
Attorney, Agent or Firm:
Hajime Amano