Title:
Ｎ−ヒドロキシホルムアミド誘導体およびそれを含有する医薬
Document Type and Number:
Japanese Patent JP5808743
Kind Code:
B2
Abstract:
A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof:
wherein X represents a phenylene group; Y represents a hydrogen atom, -(CH 2 ) m R 1 or the like; R 1 represents -NR 5 COR 2 , -NR 5 SO 2 R 2 or -NR 3 R 4 ; R 2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R 3 and R 4 represent a C1-C6 alkyl group and the like; R 5 represents a hydrogen atom or a C1-C6 alkyl group or the like; m indicates an integer of from 0 to 4; and Z represents a hydrogen atom or a C1-C6 alkyl group.
Inventors:
Kentaro Kawai
Shigeru Miyamoto
Shimano Honest
Makoto Haino
Shigeru Miyamoto
Shimano Honest
Makoto Haino
Application Number:
JP2012523866A
Publication Date:
November 10, 2015
Filing Date:
July 05, 2011
Export Citation:
Assignee:
Kaken Pharmaceutical Co., Ltd.
International Classes:
C07C317/32; A61K31/16; A61K31/5375; A61P1/02; A61P1/04; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P31/00; A61P31/04; A61P35/00; A61P37/00; A61P43/00; C07D295/12
Domestic Patent References:
| JP2006502990A | ||||
| JP2006515319A | ||||
| JP2002501945A | ||||
| JP11511179A |
Foreign References:
| WO2003022801A1 |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes