ＢＣＬ－２阻害剤としてのＮ－（フェニルスルホニル）ベンズアミドおよび関連化合物 - THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Title:

ＢＣＬ－２阻害剤としてのＮ－（フェニルスルホニル）ベンズアミドおよび関連化合物

Document Type and Number:

Japanese Patent JP7205903

Kind Code:

B2

Abstract:

The present disclosure provides compounds having Formula I-A:and the pharmaceutically acceptable salts and solvates thereof, wherein A, X¹, X², X³ R^1a, R^1b, E, andare as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.

Inventors:

Xiaomon Wang
Chen Chien Young

Application Number:

JP2019135624A

Publication Date:

January 17, 2023

Filing Date:

July 23, 2019

Export Citation:

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Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

International Classes:

C07D471/04

Domestic Patent References:

JP2013527202A
JP2012515224A
JP6651180B2
JP2013526612A
JP2012528178A
JP2012511015A
JP2013540823A
JP2013543894A

Attorney, Agent or Firm:

Aoki Atsushi
Shinji Mihashi
Junichi Tsuruta
Tomohiro Nanzan
Youichi Watanabe
Kazuhiro Nakamura

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