NEW MATERIAL: A compound represented by formula I (wherein R1 is H, a 1-10C saturated or unsaturated linear or branched hydrocarbon group, a 3-9C cyclohydrocarbon group, a 4-12C cycloalkylalkyl or a 7-10C arylalkyl; R2 is H, a halogen, CN, methyl which may be substituted, carboxyl which may be in the form of a derivative, a 2-10C alkanoyl which may be substituted or benzoyl which may be substituted; R3 is H or benzyloxy which may be substituted; and X is CN=N, formula II or S).
EXAMPLE: 2-[1-(1-Imidazolyl) butyl]-5bromothiophene.
USE: An estrogen biosynthesis inhibitor (aromatase inhibitor).
PREPARATION: A compound of formula III (wherein Z is an eliminable group) is reacted with a compound of formula IV (wherein M is H or an alkali metal) to obtain a compound of formula I.
| WO/1999/016771 | CONDENSED BENZOTHIOPYRANIC COMPOUNDS |
| WO/1994/003439 | ANTIPROLIFERATIVE TRICYCLIC COMPOUNDS |
| JP2010509392 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and their use |
RORUFU BOORUMAN
DEBUITSUTO HENDAASON
NISHINO YUKISHIGE
