Title:
N-TERMINUS MODIFIED ANALOG OF LHRH
Document Type and Number:
Japanese Patent JP2005170950
Kind Code:
A
Abstract:
To provide a medicine inhibiting activity of luteinizing hormone releasing hormone (LHRH) as a remedy for sex steroid much related diseases.
Decapeptides and undecapeptides substituted on the N-terminal nitrogen atom by acyl groups (which include furo-2-yl, isonicotinyl, nicotinyl, 2-quinolinecarbonyl, 3-quinolinecarbonyl, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl and tetrahydrofur-2-oyl) are potent antagonists of LHRH. The antagonists of LHRH are useful for suppressing the levels of sex hormones in mammals.
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Inventors:
HAVIV FORTUNA
FITZPATRICK TIMOTHY D
SWENSON ROLF E
NICHOLS CHARLES J
MORT NICHOLAS A
FITZPATRICK TIMOTHY D
SWENSON ROLF E
NICHOLS CHARLES J
MORT NICHOLAS A
Application Number:
JP2004378980A
Publication Date:
June 30, 2005
Filing Date:
December 28, 2004
Export Citation:
Assignee:
TAP HOLDINGS INC
International Classes:
A61K38/00; A61P5/04; A61P5/12; A61P5/28; A61P5/32; A61P13/02; A61P13/08; A61P15/00; A61P15/08; A61P15/18; A61P25/04; A61P35/00; C07K7/06; C07K7/08; C07K7/23; (IPC1-7): C07K7/06; A61K38/00; A61P5/04; A61P5/28; A61P5/32; A61P13/08; A61P15/00; A61P15/08; A61P15/18; A61P35/00; C07K7/08
Attorney, Agent or Firm:
Yoshio Kawaguchi