Title:
【発明の名称】モノマージオールおよびそれらから形成されるホスフェート結合オリゴマー
Document Type and Number:
Japanese Patent JP3072127
Kind Code:
B2
Abstract:
Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.
Inventors:
Cook, Philip Dunn
Ascedo, Oscar El
Davis, Peter W
Ecker, David Jay
Herbert, Normand
Ascedo, Oscar El
Davis, Peter W
Ecker, David Jay
Herbert, Normand
Application Number:
JP51870095A
Publication Date:
July 31, 2000
Filing Date:
January 11, 1995
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
C07D295/08; A61K31/40; A61K31/403; A61K31/404; A61K31/70; A61K31/7088; A61P1/00; A61P1/04; A61P17/00; A61P17/04; A61P29/00; A61P43/00; C07B61/00; C07C31/20; C07C43/13; C07C43/178; C07C237/04; C07C317/16; C07C323/10; C07C325/00; C07C327/20; C07C327/38; C07C333/02; C07D207/325; C07D209/08; C07D233/60; C07D239/24; C07D239/26; C07D239/42; C07D239/54; C07D279/18; C07D471/04; C07D473/18; C07D473/26; C07D473/34; C07F9/08; C07F9/141; C07F9/143; C07F9/22; C07F9/24; C07F9/572; C07F9/59; C07F9/6503; C07F9/6506; C07F9/6509; C07F9/6512; C07F9/6521; C07F9/6533; C07F9/6547; C07F9/6561; C07H21/00; C08G79/02; C08G79/04; C12Q1/68; (IPC1-7): C07C31/20; C07C43/178; C07D239/24; C07D473/26; C07F9/08; C07F9/22
Domestic Patent References:
| JP3236396A | ||||
| JP2503146A |
Other References:
【文献】Nucleic Acids Research,17[22](1989)p.8917-p.8929
【文献】Collection Czechoslov.Chem.Commun.,40[1](1975)p.187-p.214
【文献】Nucleic Acids Research,20[13](1992)p.3411-p.3147
【文献】Nucleic Acids Research,19[10](1991)p.2587-p.2593
【文献】Nucleic Acids Research,17[18](1989)p.7179-p.7186
【文献】Nucleic Acids Research,21[8](1993)p.1705-p.1712
【文献】Bioconjugate Chemistry,4[5](1993)p.380-p.385
【文献】Bioconjugate Chemistry,3[6](1992)p.559-p.562
【文献】Tetrahedron Letters,27[46](1986)p.5575-p.5578
【文献】Collection Czechoslov.Chem.Commun.,40[1](1975)p.187-p.214
【文献】Nucleic Acids Research,20[13](1992)p.3411-p.3147
【文献】Nucleic Acids Research,19[10](1991)p.2587-p.2593
【文献】Nucleic Acids Research,17[18](1989)p.7179-p.7186
【文献】Nucleic Acids Research,21[8](1993)p.1705-p.1712
【文献】Bioconjugate Chemistry,4[5](1993)p.380-p.385
【文献】Bioconjugate Chemistry,3[6](1992)p.559-p.562
【文献】Tetrahedron Letters,27[46](1986)p.5575-p.5578
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)