Title:
活性物質の標的化送達用ナノ粒子
Document Type and Number:
Japanese Patent JP2009508936
Kind Code:
A
Abstract:
The present invention concerns a delivery system comprising a polymer-based nanoparticle; and a linker comprising a first portion non-covalently anchored to said nanoparticle, wherein at least part of said first portion comprises a hydrophobic/lipophilic segment embedded in said nanoparticle; and a second portion comprising a maleimide compound exposed at the outer surface of said nanoparticle. In accordance with one embodiment, the delivery system comprises one or more targeting agents, each covalently bound to said maleimide compound. In accordance with yet another embodiment, the delivery system comprises a drug. A specific example for a linker in accordance with the invention is octadecyl-4-(maleimideomethyl)cyclohexane-carboxylic amide (OMCCA).
Inventors:
Benita, Simon
Nebo, Divoton
Gold stain, danny
Nebo, Divoton
Gold stain, danny
Application Number:
JP2008531879A
Publication Date:
March 05, 2009
Filing Date:
September 20, 2006
Export Citation:
Assignee:
Issam Research Development Company
International Classes:
A61K9/51; A61K31/337; A61K39/395; A61K47/34; A61K47/48; A61K49/00; A61P35/00
Domestic Patent References:
| JP2007501797A | 2007-02-01 |
Foreign References:
| US20050042298A1 | 2005-02-24 | |||
| US20050180997A1 | 2005-08-18 |
Other References:
JPN5008014393; ＯＬＩＶＩＥＲ: ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＳＯＣＩＥＴＹ ＦＯＲ ＥＸＰＥＲＩＭＥＮＴＡＬ ＮＥＵＲＯＴＨＥＲＡＰＥＵＴＩＣＳ Ｖ２ Ｎ１, 200501, Ｐ１０８-１１９
JPN5008014394; ＯＬＩＶＩＥＲ ＪＥＡＮ-ＣＨＲＩＳＴＯＰＨＥ: ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＲＥＳＥＡＲＣＨ Ｖ１９ Ｎ８, 200208, Ｐ１１３７-１１４３
JPN5008014394; ＯＬＩＶＩＥＲ ＪＥＡＮ-ＣＨＲＩＳＴＯＰＨＥ: ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＲＥＳＥＡＲＣＨ Ｖ１９ Ｎ８, 200208, Ｐ１１３７-１１４３
Attorney, Agent or Firm:
Mieko Kashihara
Goichi Takahashi
Masahito Shibata
Yonemura Michiko
Goichi Takahashi
Masahito Shibata
Yonemura Michiko