Title:
NEUREGULIN BASED METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASES
Document Type and Number:
Japanese Patent JP2018052957
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide pharmaceutical compositions containing a prophylactic or therapeutic agent effective to various cardiovascular diseases or disorders in mammals (particularly humans), such as viral myocarditis, and dilated (congestive) cardiomyopathy, cardiotoxicity of a prophylactic or therapeutic agent [e.g. Adriamycin (ADM)], or myocardial contraction.SOLUTION: The invention provides a pharmaceutical composition combined with prophylactic or therapeutic agents containing an effective amount of neuregulin protein or a functional fragment thereof, a nucleic acid encoding a neuregulin protein or a functional fragment thereof, a drug enhancing a production and/or function of the neuregulin, or a prophylactic or therapeutic agent for viral myocarditis or dilated (congestive) cardiomyopathy (DCM). Preferably, the neuregulin exerts its anti-viral myocarditis or anti-DCM activity via binding with ErbB2-ErbB4 receptors.SELECTED DRAWING: None
Inventors:
ZHOU MINGDONG
Application Number:
JP2017214721A
Publication Date:
April 05, 2018
Filing Date:
November 07, 2017
Export Citation:
Assignee:
ZENSUN SHANGHAI SCI TECH LTD
International Classes:
A61K38/18; A61K31/00; A61K45/00; A61K31/04; A61K31/122; A61K31/137; A61K31/138; A61K31/165; A61K31/185; A61K31/21; A61K31/335; A61K31/355; A61K31/375; A61K31/401; A61K31/403; A61K31/43; A61K31/4422; A61K31/46; A61K31/5377; A61K31/5415; A61K31/55; A61K31/554; A61K31/616; A61K31/704; A61K35/30; A61K38/00; A61K38/16; A61K38/19; A61K38/20; A61K38/21; A61K38/22; A61K38/45; A61K38/46; A61K38/48; A61K38/49; A61K38/55; A61K38/57; A61K45/06; A61K48/00; A61P7/02; A61P7/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P25/18; A61P25/24; A61P31/00; A61P31/04; A61P35/00; A61P35/02; A61P39/06; A61P43/00; C07K14/475; C12N15/10
Foreign References:
| WO2000064400A2 | 2000-11-02 | |||
| CN1276381A | 2000-12-13 |
Other References:
富永 慶晤，鈴木 忠: "癌治療学（下） 化学療法剤による副作用 心毒性をきたす抗癌剤", 日本臨牀, vol. 第４７巻，増刊号, JPN6018030633, 1989, pages ｐ．１０１７−１０２４
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Ayako Nakamura
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Ayako Nakamura
Satoshi Morimoto