Title:
新規な結合剤-薬物複合体(ADC)およびそれらの使用
Document Type and Number:
Japanese Patent JP2014515753
Kind Code:
A
Abstract:
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
Inventors:
Hans-Georg Lerchen
Sheriff El Shaik
Rudolph Bayer
Sandra Bruder
Beatrix Stelte-Ludwig
Hannah Jerisen
Christoph Marrelt
Jimone Grafen
Heike Petruru
Joachim Schumacher
Lars Linden
Jörg Vilda
Charlotte Christine Coppitz
Sven Golfia
Illing Heissler
Axel harenga
Karl-Heinz Thielauf
Zandra Volkovsky
Sheriff El Shaik
Rudolph Bayer
Sandra Bruder
Beatrix Stelte-Ludwig
Hannah Jerisen
Christoph Marrelt
Jimone Grafen
Heike Petruru
Joachim Schumacher
Lars Linden
Jörg Vilda
Charlotte Christine Coppitz
Sven Golfia
Illing Heissler
Axel harenga
Karl-Heinz Thielauf
Zandra Volkovsky
Application Number:
JP2014505641A
Publication Date:
July 03, 2014
Filing Date:
April 20, 2012
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
Bayer Pharma Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
International Classes:
A61K38/00; A61K39/395; A61K45/00; A61K47/42; A61K47/48; A61P35/00; A61P35/02; C07K1/10; C07K5/02; C07K14/705; C07K16/28; C07K16/46; C07K19/00; C12N9/88
Domestic Patent References:
| JP2014505642A | 2014-03-06 | |||
| JP2013533228A | 2013-08-22 | |||
| JP2013540114A | 2013-10-31 | |||
| JP2014515735A | 2014-07-03 |
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Sakurai Yoko
Aoyama Aoi
Michiko Matsutani
Sakurai Yoko