Title:
新規アミン誘導体またはその塩
Document Type and Number:
Japanese Patent JP6466171
Kind Code:
B2
Abstract:
A novel amine derivative expressed by general formula (1)
(in the formula: G 1 , G 2 , and G 3 are the same or different and represent CH or a nitrogen atom; R 1 represents a chlorine atom, an optionally-substituted C 3-8 cycloalkyl group, or the like; R 2 represents -COOR 5 (in the formula, R 5 represents a hydrogen atom or a carboxyl protective group), or the like; R 3 represents a hydrogen atom, or the like; and R 4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
Inventors:
Tadashi Tanaka
Yoshitake Konishi
Kubo Daisuke
Fujino Shodo
Issei Doi
Daisuke Nakagawa
Tatsuya Murakami
Takayuki Yamakawa
Yoshitake Konishi
Kubo Daisuke
Fujino Shodo
Issei Doi
Daisuke Nakagawa
Tatsuya Murakami
Takayuki Yamakawa
Application Number:
JP2014544546A
Publication Date:
February 06, 2019
Filing Date:
October 30, 2013
Export Citation:
Assignee:
FUJIFILM Toyama Chemical Co., Ltd.
FUJIFILM Corporation
FUJIFILM Corporation
International Classes:
C07D209/08; A61K31/4035; A61K31/404; A61K31/416; A61K31/4184; A61K31/423; A61K31/427; A61K31/428; A61K31/437; A61K31/4439; A61K31/454; A61K31/455; A61K31/4704; A61K31/4709; A61K31/472; A61K31/4725; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61K31/538; A61P1/04; A61P1/16; A61P3/10; A61P9/10; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D209/12; C07D209/34; C07D209/38; C07D209/42; C07D209/46; C07D209/48; C07D213/80; C07D215/38; C07D217/24; C07D231/56; C07D235/08; C07D235/26; C07D241/44; C07D263/58; C07D277/68; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D405/14; C07D413/12; C07D417/04; C07D417/06; C07D417/12; C07D471/04; C07F7/08
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Other References:
MEESALA, R. et al.,A short route to the synthesis of pyrroloacridines via Ullmann-Goldberg condensation,Tetrahedron Letters,2010年,Vol.51, No.2,p.422-424
BALDWIN, R. W. et al.,Further studies on the influence of peripheral ring substitution on the carcinogenicity of tricycloquinazoline,Biochemical Pharmacology,1965年,Vol.14, No.3,p.323-331
BUNKER, A. M. et al.,1,3-Diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists,Bioorganic & Medicinal Chemistry letters,1996年,Vol.6, No.9,p.1061-1066
PARTRIDGE,M.W. et al,Cyclic amidines. XV. Derivatives of tricycloquinazoline,Journal of the Chemical Society,1962年,p.2549-56
BRASS,K.,Oxidation of anillnoquinones to benzidine derivatives. II,Berichte der Deutschen Chemischen Gesellschaft,1913年,Vol.46,p.2907-12
ALLAIS,A. et al,Analgesic and antiinflammatory activity of 4-(2-alkoxycarbonyl-phenyl amino)quinolines,Chim. Therap,1966年,No.2,p.65-70
BALDWIN, R. W. et al.,Further studies on the influence of peripheral ring substitution on the carcinogenicity of tricycloquinazoline,Biochemical Pharmacology,1965年,Vol.14, No.3,p.323-331
BUNKER, A. M. et al.,1,3-Diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists,Bioorganic & Medicinal Chemistry letters,1996年,Vol.6, No.9,p.1061-1066
PARTRIDGE,M.W. et al,Cyclic amidines. XV. Derivatives of tricycloquinazoline,Journal of the Chemical Society,1962年,p.2549-56
BRASS,K.,Oxidation of anillnoquinones to benzidine derivatives. II,Berichte der Deutschen Chemischen Gesellschaft,1913年,Vol.46,p.2907-12
ALLAIS,A. et al,Analgesic and antiinflammatory activity of 4-(2-alkoxycarbonyl-phenyl amino)quinolines,Chim. Therap,1966年,No.2,p.65-70
Attorney, Agent or Firm:
Asamura patent office