腫瘍成長、血管新生および転移を妨害する癌標的に対する新規抗体

Japanese Patent JP2011521619

A

The present invention provides antibodies that target the first-third domains of N-cadherein and the fourth domain of N-cadherin, for diagnosis and therapy of cancers related to N-cadherein. Methods of diagnosis and treatment utilizing these antibodies are also described.

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JP2002542829	INDUSTRIAL APPLICABILITY: A method for producing a plant having a higher oleic acid content.

Robert E. Leeter
Zeb Weinberg

JP2011503226A

July 28, 2011

April 03, 2009

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The Regents of The University of California

C12N5/10; A61K39/395; A61P13/08; A61P13/10; A61P35/00; A61P35/04; A61P43/00; C07K16/28; C12N15/02; C12P21/08; C12Q1/04; G01N33/15; G01N33/50; G01N33/574

WO2010054377A2	2010-05-14
WO2007109347A2	2007-09-27

JPN6013055980; ＴＡＮＡＫＡ，Ｈ．　ｅｔ　ａｌ．: 'Ｍｏｎｏｃｌｏｎａｌ　ａｎｔｉｂｏｄｙ　ｔａｒｇｅｔｉｎｇ　ｏｆ　Ｎ-ｃａｄｈｅｒｉｎ　ｉｎｈｉｂｉｔｓ　ｐｒｏｓｔａｔｅ　ｃａｎｃｅｒ　ｇｒｏｗｔｈ，　ｍｅｔａｓｔａｓｉｓ　ａｎｄ　ｃａｓｔｒａｔｉ' Ｎａｔ．　Ｍｅｄ． Ｖｏｌ．１６，　Ｎｏ．１２, 201012, ｐｐ．１４１４-２０
JPN6013055982; ＳＨＩＲＡＹＯＳＨＩ，Ｙ．　ｅｔ　ａｌ．: 'Ｃａｄｈｅｒｉｎ　ｃｅｌｌ　ａｄｈｅｓｉｏｎ　ｍｏｌｅｃｕｌｅｓ　ｗｉｔｈ　ｄｉｓｔｉｎｃｔ　ｂｉｎｄｉｎｇ　ｓｐｅｃｉｆｉｃｉｔｉｅｓ　ｓｈａｒｅ　ａ　ｃｏｍｍｏｎ　ｓｔｒｕｃｔｕｒｅ．' ＥＭＢＯ　Ｊ． Ｖｏｌ．５，　Ｎｏ．１０, 198610, ｐｐ．２４８５-８
JPN6013055984; ＨＡＴＴＡ，Ｋ．　ｅｔ　ａｌ．: 'Ｃｌｏｎｉｎｇ　ａｎｄ　ｅｘｐｒｅｓｓｉｏｎ　ｏｆ　ｃＤＮＡ　ｅｎｃｏｄｉｎｇ　ａ　ｎｅｕｒａｌ　ｃａｌｃｉｕｍ-ｄｅｐｅｎｄｅｎｔ　ｃｅｌｌ　ａｄｈｅｓｉｏｎ　ｍｏｌｅｃｕｌｅ：　ｉｔｓ　ｉｄｅｎｔ' Ｊ．　Ｃｅｌｌ　Ｂｉｏｌ． Ｖｏｌ．１０６，　Ｎｏ．３, 198803, ｐｐ．８７３-８１
JPN6013055986; ＨＡＲＲＩＳＯＮ，Ｏ．Ｊ．　ｅｔ　ａｌ．: 'Ｔｈｅ　ｍｅｃｈａｎｉｓｍ　ｏｆ　ｃｅｌｌ　ａｄｈｅｓｉｏｎ　ｂｙ　ｃｌａｓｓｉｃａｌ　ｃａｄｈｅｒｉｎｓ：　ｔｈｅ　ｒｏｌｅ　ｏｆ　ｄｏｍａｉｎ　１．' Ｊ．　Ｃｅｌｌ　Ｓｃｉ． Ｖｏｌ．１１８，　Ｎｏ．４, 20050215, ｐｐ．７１１-２１

Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa

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