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Title:
NEW ANTIMICROBIAL LACTAM-QUINOLONES
Document Type and Number:
Japanese Patent JPH0314578
Kind Code:
A
Abstract:

NEW MATERIAL: Compounds of formula I {Q is formula II [A1 is N or CR7 (R7 is H, a halogen, alkyl, etc.); A2 is N or CR2 (R2 is H or a halogen); A3 is N or CH; R1 is H or R15 (R15 is an alkyl, carbon ring, etc.); R3 is H, a halo gen, etc.; R4 is OH; R6 is H, a halogen, etc.]; B is formula III; R10 is H, an alkyl, alkenyl, etc.; R11 is H, an alkoxy, etc.; R12 is CR8a (R8a is H, an alkyl, etc.), etc.; R13 is CHR33 or CR33 (R33 is H or COOH), etc.; R14 is none or W-C'''-R34 (W is O, S, etc.; R37 is none or an alkyl; C''' is a 5- or 6-membered ring), etc.; L is L'-X2t-R39-L' [L' is Q' or X2Q' (Q' is R15, etc.); X2 is O, S, etc.; t is 0 or 1; R39 is an alkyl, an alkenyl, etc.], etc.}.

EXAMPLE: A compound of formula IV.

USE: An antimicrobial agent for therapy or prophylaxis of human or other aminal infectious disease.

PROCESS: A lactam-containing part B or quinolone part Q is prepared respectively and both parts are bonded together.


Inventors:
TOOMASU PUROTSUSAA DEMASU JIYU
RONARUDO YUUJIIN HOWAITO
Application Number:
JP27699289A
Publication Date:
January 23, 1991
Filing Date:
October 24, 1989
Export Citation:
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Assignee:
NORWICH EATON PHARMA
International Classes:
C07D499/897; A61K31/431; A61K31/47; A61K31/535; A61K31/545; A61K31/546; A61P31/04; A61P43/00; C07D215/56; C07D401/04; C07D401/12; C07D401/14; C07D409/12; C07D417/12; C07D417/14; C07D455/04; C07D463/00; C07D463/16; C07D471/04; C07D477/10; C07D477/14; C07D477/20; C07D487/04; C07D498/04; C07D498/06; C07D499/00; C07D499/04; C07D499/86; C07D499/87; C07D499/88; C07D501/00; C07D501/18; C07D501/20; C07D501/34; C07D503/00; C07D505/00; C07D513/04; C07D513/06; C07D513/16; C07D519/00; C07D519/06; C07D521/00; C07F9/6561; (IPC1-7): A61K31/47; A61K31/535; A61K31/545; C07D401/14; C07D409/12; C07D417/12; C07D417/14; C07D463/00; C07D498/053; C07D498/06; C07D499/88; C07D501/18; C07D501/20; C07D513/04; C07D513/06; C07D513/16; C07D519/00; C07D521/00; C07F9/6561
Attorney, Agent or Firm:
Kazuo Sato (2 outside)