Title:
癌間質の構成因子に対して特異的結合能を有する物質と抗腫瘍性化合物との複合体による新規の癌ターゲティング治療
Document Type and Number:
Japanese Patent JP5593488
Kind Code:
B2
Abstract:
The present invention is intended to provide a pharmaceutical for tumor treatment that stays specifically in interstitium for a long time and exhibits an effect, and provides a complex consisting of a substance having specific binding affinity for stroma and an antitumor compound bound to the substance via a linker.
Inventors:
Yasuhiro Matsumura
Masahiro Yasunaga
Manabe History 乃
Masahiro Yasunaga
Manabe History 乃
Application Number:
JP2010537830A
Publication Date:
September 24, 2014
Filing Date:
November 17, 2009
Export Citation:
Assignee:
Independent administrative institution national cancer research center
Independent administrative institution Institute of Physical and Chemical Research
Independent administrative institution Institute of Physical and Chemical Research
International Classes:
A61K39/395; A61K9/127; A61K45/00; A61K47/34; A61K47/48; A61P35/00; C07K16/18; A61K31/4745
Domestic Patent References:
| JP2005510246A | 2005-04-21 |
Foreign References:
| WO2007069709A1 | 2007-06-21 | |||
| WO2007112193A2 | 2007-10-04 | |||
| WO2007038658A2 | 2007-04-05 |
Other References:
JPN6014006833; ＫＡＳＰＡＲ，Ｍ． ｅｔ ａｌ: 'Ｆｉｂｒｏｎｅｃｔｉｎ ａｓ ｔａｒｇｅｔ ｆｏｒ ｔｕｍｏｒ ｔｈｅｒａｐｙ' Ｉｎｔ Ｊ Ｃａｎｃｅｒ Ｖｏｌ．１１８， Ｎｏ．６, 2006, ｐ．１３３１-１３３９
JPN6009067182; ＩＭＡＭＵＲＡ，Ｔ． ｅｔ ａｌ: 'Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌ ｓｔａｉｎｉｎｇ ｆｏｒ ｔｙｐｅ ＩＶ ｃｏｌｌａｇｅｎ ａｎｄ ｌａｍｉｎｉｎ ｉｎ ｔｈｅ ｓｔｒｏｍａ ｏｆ ｈｕｍａｎ ｐａｎｃｒｅａｔｉｃ ｃａｎｃ' Ｉｎｔ Ｊ Ｐａｎｃｒｅａｔｏｌ Ｖｏｌ．１８， Ｎｏ．２, 1995, ｐ．９５-９９
JPN6009067182; ＩＭＡＭＵＲＡ，Ｔ． ｅｔ ａｌ: 'Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌ ｓｔａｉｎｉｎｇ ｆｏｒ ｔｙｐｅ ＩＶ ｃｏｌｌａｇｅｎ ａｎｄ ｌａｍｉｎｉｎ ｉｎ ｔｈｅ ｓｔｒｏｍａ ｏｆ ｈｕｍａｎ ｐａｎｃｒｅａｔｉｃ ｃａｎｃ' Ｉｎｔ Ｊ Ｐａｎｃｒｅａｔｏｌ Ｖｏｌ．１８， Ｎｏ．２, 1995, ｐ．９５-９９
Attorney, Agent or Firm:
Takashima 1
Kyoko Doi
Kamata 光宜
Tamura Yasaka child
Kenji Yamamoto
Murata Miyuki
Koike 順造
Hirofumi Toma
Kyoko Doi
Kamata 光宜
Tamura Yasaka child
Kenji Yamamoto
Murata Miyuki
Koike 順造
Hirofumi Toma