Title:
新規糖尿病治療剤
Document Type and Number:
Japanese Patent JP6999331
Kind Code:
B2
Abstract:
A nobel therapeutic agent for diabetes which can suppress occurrence of side effects such as persistent hypoglycemia is provided. The active ingredient is a derivative of 1,1-diphenylsemicarbazide or 1,1-diphenylthiosemicarbazide. In particular, the active ingredient is a derivative of 1,1-diphenyl-4-cyclohexyl-semicarbazide or 1,1-diphenyl-4-cyclohexyl-thiosemicarbazide exhibiting hypoglycemic action when orally administered.
Inventors:
Kiyono Susumu
Kenji Sugawara
Ichiro Mori
Akio Matsumoto
Reien Yoshie
Kenji Sugawara
Ichiro Mori
Akio Matsumoto
Reien Yoshie
Application Number:
JP2017163122A
Publication Date:
February 10, 2022
Filing Date:
August 28, 2017
Export Citation:
Assignee:
jcr pharma corporation
National University Corporation Kobe University
National University Corporation Chiba University
National University Corporation Kobe University
National University Corporation Chiba University
International Classes:
C07C281/06; A61K31/175; A61P3/10; C07C337/06
Domestic Patent References:
| JP2003211840A | ||||
| JP2006517199A | ||||
| JP2005532402A |
Foreign References:
| WO2004106289A1 | ||||
| US20060142285 |
Other References:
PACILLY, C.,The action of aliphatic isocyanates on hydrazine derivatives,Recueil des Travaux Chimiques des Pays-Bas,1936年,Vol.55, No.2,pp.101-121,doi:10.1002/recl.19360550203
REGISTRY(STN)[ONLINE],2003年04月15日,CAS登録番号:502969-01-9 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],1987年02月07日,CAS登録番号:106437-84-7 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],2002年09月26日,CAS登録番号:455309-99-6 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],2006年08月23日,CAS登録番号:903805-03-8 retrieved on 2021.1.12
GINWALA, K. et al.,Synthesis of 1,1-diphenyl 4-substituted thiosemicarbazides,Current Science,1963年,Vol.32, No.4,pp.159-160
SCOTT, F.,Polynitrogen systems from the hydrazinocarbonic acids. V. Aminolytic reactions of N,N-diphenylcarbamyl azide,Journal of the American Chemical Society,1957年,Vol.79,pp.6077-6082
REGISTRY(STN)[ONLINE],2003年04月15日,CAS登録番号:502969-01-9 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],1987年02月07日,CAS登録番号:106437-84-7 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],2002年09月26日,CAS登録番号:455309-99-6 retrieved on 2021.1.12
REGISTRY(STN)[ONLINE],2006年08月23日,CAS登録番号:903805-03-8 retrieved on 2021.1.12
GINWALA, K. et al.,Synthesis of 1,1-diphenyl 4-substituted thiosemicarbazides,Current Science,1963年,Vol.32, No.4,pp.159-160
SCOTT, F.,Polynitrogen systems from the hydrazinocarbonic acids. V. Aminolytic reactions of N,N-diphenylcarbamyl azide,Journal of the American Chemical Society,1957年,Vol.79,pp.6077-6082
Attorney, Agent or Firm:
Yamamoto Yoshiki
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