To provide a hydroxycarboxamide derivative exhibiting potent and selective cathepsin K inhibitory action and useful for producing a cyclic amide derivative of a potential bone resorption inhibitor useful as a therapeutic agent for bone diseases such as osteoporosis.
The hydroxycarboxamide derivative is represented by the general formula. Wherein, ring A is a 5-7C saturated cyclic alkyl or a 3-6C saturated heterocycle containing a heteroatom, R1 is a substituted alkyl, a substituted alkenyl, a substituted amino, a substituted alkoxy, a substituted alkylthio, a substituted carbamoyl, a substituted sulfonamide or a substituted amide, R2 is H, a (substituted) alkyl, a (substituted) aromatic hydrocarbon or a (substituted) heterocycle, and R5 and R6 are the same or different and H, a (substituted) alkyl, a (substituted) aromatic hydrocarbon or a (substituted) heterocycle.
| JP2008518903 | A novel compound of substituted and unsubstituted adamantylamide |
| WO/1986/000066 | N-SUBSTITUTED BUTYRAMIDE DERIVATIVES |
| WO/2003/076430 | AMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE |
KOBAYASHI NOBUO
TANABE NAOKO
SHOJI TSUNEO
SHIBATA MASAHIRO
SEKINE AKIHIRO
MICHIYOSHI KIMIYOSHI
Fumio Shinoda