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Title:
NEW MEDICAL USE OF TACHYKININ ANTAGONIST
Document Type and Number:
Japanese Patent JP2000191522
Kind Code:
A
Abstract:

To obtain a medicine for treating vomit induced by cancer chemotherapeutics, radiation hangover, etc. by adding a tachykinin antagonist useful for treating various disorders such as inflammatory diseases, allergic syndromes, etc. as an active ingredient.

This medicine contains a tachykinin antagonist {preferably 2-ammonium-1-[[3,5-bis(trifluoromethyl)phenyl]methyloxy]-3,3-diphenylpropane, (2S,3S)-3-(2-methoxy-5-trifluoromethoxybenzyl)-amino-2-phenylpiperidine}, such as a compound of the formula [(n) is 1-3: X is O or S; R1 is a 1-6C alkyl, a 2-6C alkenyl, a 2-6C alkynyl, a halogen, cyano, nitro or the like; R2 is phenyl, naphthyl, indazolyl, thienyl, furyl or the like; R4, R5 are each H, a halogen, a 1-6C alkyl, oxo or the like; and R8 is H, a 1-6C alkyl or the like], as an active ingredient.


Inventors:
HAGAN RUSSELL M
BUNCE KEITH T
Application Number:
JP34935299A
Publication Date:
July 11, 2000
Filing Date:
March 18, 1994
Export Citation:
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Assignee:
GLAXO GROUP LTD
International Classes:
A61K31/00; A61K31/135; A61K31/165; A61K31/35; A61K31/352; A61K31/397; A61K31/407; A61K31/439; A61K31/445; A61K31/451; A61K31/47; A61K33/24; A61K38/00; A61P1/08; A61P43/00; C07D207/00; C07D209/00; C07D209/44; C07D209/82; C07D211/56; C07D215/14; A61K31/14; C07D227/04; C07D227/087; C07D275/04; C07D311/82; C07D453/00; C07D453/02; C07D471/18; C07D487/08; (IPC1-7): A61K31/14; A61K31/35; A61K31/397; A61K31/407; A61K31/439; A61K31/445; A61K31/47; A61K33/24; A61K38/00; A61P1/08; A61P43/00; C07D215/14; C07D227/04; C07D227/087; C07D275/04; C07D311/82; C07D453/00; C07D453/02; C07D471/18; C07D487/08
Attorney, Agent or Firm:
Kazuo Sato (2 outside)



 
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