Title:
NEW METHOD FOR PRODUCING BOTH 2'-FLUOROPYRIMIDINE NUCLEOSIDE AND 2'-FLUOROPURINE NUCLEOSIDE
Document Type and Number:
Japanese Patent JP2770162
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject compound useful for therapy against AIDS, etc., by reacting a specific compound with an acid halide, adding silane and then reacting the resultant product with such a reagent as ammonia.
SOLUTION: This compound is obtained by reacting a compound of formula I [R is H, a 7-20C alloyl, a 6-20C aryl, etc.; R' is H, a 1-10C alkyl, a 7-20C alloyl or a 2-12C acyl], etc., with an acid halide to form a halide of formula II (X is a halogen), by adding a silane of formula B-Si(R'')3 (B is a purine or a pyrimidine; R'' is a 1-10C alkyl, a 6-20C aryl or the like) to form a compound of formula III, and then by reacting the compound of formula III with a reagent selected from a group consisting of ammonia, ammonia/methanol, BC13, sodium hydroxide, diisopropylamine and Bu4NF.
Inventors:
Marquez, Victor Yee
Doriscor, John Es
Wysocki, Ronald Jay, Junior
Sidqui, McBurray A
Doriscor, John Es
Wysocki, Ronald Jay, Junior
Sidqui, McBurray A
Application Number:
JP8056496A
Publication Date:
June 25, 1998
Filing Date:
March 08, 1996
Export Citation:
Assignee:
US COMMERCE (US)
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; C07H1/00; A61K31/7072; A61K31/7076; A61P31/12; A61P31/18; C07H13/08; C07H15/04; C07H15/203; C07H19/06; C07H19/10; C07H19/16; C07H23/00; (IPC1-7): C07H19/06; C07H1/00; C07H19/16
Attorney, Agent or Firm:
Nao Okuyama (2 outside)
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