NEW NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCE, COMPOSITION AND METHOD FOR USE THEREOF

Japanese Patent JP2011006474

A

To provide a macrolide/NSAID hybrid compound to cope with inflammatory state.

There are provided (a) new compounds represented by formula I [wherein; M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells; D represents a nonsteroidal subunit (nonsteroidal moiety) derived from nonsteroidal drug with anti-inflammatory, analgesic and/or antipyretic activity (NSAID); and L represents a linking group covalently linking M and D], (b) their pharmacologically acceptable salts, prodrugs and solvates, (c) methods and intermediates for their preparation, and (d) their use in the treatment of inflammatory diseases and conditions in humans and animals.

WO/1994/022886	HETEROATOMIC OLIGONUCLEOSIDE LINKAGES
WO/2000/069874	NOVEL CRYSTALLINE FORMS OF A MACROLIDE ANTIBIOTIC
WO/2001/030796	A PROCESS FOR PREPARING ACARBOSE WITH HIGH PURITY

MERCEP MLADEN
MESIC MILAN
TOMASKOVIC LINDA
MARKOVIC STRIBOR

JP2010211027A

January 13, 2011

September 21, 2010

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GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D O O

C07H17/00; C07H17/08; A61K31/7048; A61K31/7052; A61K31/7056; A61K31/706; A61P1/04; A61P1/10; A61P1/12; A61P1/16; A61P3/10; A61P5/14; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/00; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P17/16; A61P19/00; A61P19/02; A61P19/04; A61P19/06; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P37/06; A61P37/08

WO2000042055A2

2000-07-20

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro

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