NICOTINE RECEPTOR AGONIST IN STEM CELL AND PROGENITOR CELL RECRUITMENT

Title:

NICOTINE RECEPTOR AGONIST IN STEM CELL AND PROGENITOR CELL RECRUITMENT

Document Type and Number:

Japanese Patent JP2008291040

Kind Code:

A

Abstract:

To provide a method for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or another nicotine receptor agonist.

The method can be used in, for example, the treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia). The figure is a graph showing the capillary density (capillaries/myocyte) and the percentage of new vessels incorporating endothelial progenitor cells for saline control animals and nicotine treated animals.

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Inventors:

COOKE JOHN
JOHNSON FRANCES LAURI
PATHAK ANJALI
JANG JAMES
TSAO PHILLIP
HEESCHEN CHRISTOPHER

Application Number:

JP2008181465A

Publication Date:

December 04, 2008

Filing Date:

July 11, 2008

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR

International Classes:

A61K45/00; A61K31/40; A61K31/44; A61K31/445; A61K31/465; A61P1/04; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/08; A61P9/10; A61P9/14; A61P17/02; A61P31/12; A61P31/18; A61P37/04; A61P37/06; A61P43/00

Foreign References:

WO1997034605A1

1997-09-25

Attorney, Agent or Firm:

Naoto Uchida
Koji Okuhara

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