INTERLEUKIN-1 CONVERTING ENZYME INHIBITOR

Japanese Patent JP2008291039

A

To provide a new class compound which is an interleukin-1 converting enzyme inhibitor.

An ICE (interleukin-1 converting enzyme) inhibitor characterized by a specific structure and pharmacological characteristics is provided. A pharmaceutical composition containing the compound is also provided. The compound and the pharmaceutical composition are sufficiently suitable for inhibiting the ICE activity, and as a result, can advantageously be used as medicines for interleukin-1-mediated diseases (including inflammatory diseases, autoimmune diseases and nerve denaturating diseases). A method for inhibiting ICE activities and a method for treating interleukin-1-mediated diseases using the compound and the composition are also provided.

WO/2005/061468	HALOGENATED BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
JP2002356480	METHOD FOR PRODUCING TRANS-(5R)-2,4,5-TRISUBSTITUTED 2- OXAZOLINE
JP5457501	Lipoxin A4 analog

BEMIS GUY W
GOLEC JULIAN M C
LAUFFER DAVID J
MULLICAN MICHAEL D
MURCKO MARK A
LIVINGSTON DAVID J

JP2008166634A

December 04, 2008

June 25, 2008

Click for automatic bibliography generation  

VERTEX PHARMACEUT INC

C07D263/24; C07K5/08; A61K31/42; A61K31/421; A61K38/00; A61K38/06; A61K38/07; A61K45/00; A61P25/00; A61P25/28; A61P29/00; A61P29/02; A61P35/00; A61P37/00; A61P43/00; C07C229/22; C07C233/41; C07C233/83; C07C311/30; C07C317/26; C07D521/00; C07K5/02; C07K5/023; C07K5/04; C07K5/06; C07K5/10; C07K

JPH05271274A

1993-10-19

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

Previous Patent: BIFUNCTIONAL CROWN ETHER

Next Patent: NICOTINE RECEPTOR AGONIST IN STEM CELL AND PROGENITOR CELL RECRUITMENT