To provide a compound effective for a therapeutic agent or a prophylactic agent of rejection reaction at organ transplantation, autoimmune disease or the like.
There is provided a compound represented by formula (I) or a salt thereof. [In the formula, X1 is CR7 or nitrogen; X2 is CH or nitrogen; X3 and X4 are a group bonded to each other: -X3----X4- (wherein, the group is -CONR8-, -C(R9)=N- or the like); R1, R2, R3, R4 and R7 are each independently hydrogen, halogen, 1-6C alkyl or the like; R5 is hydrogen or -NHR10; R6 is hydrogen, 1-6C alkyl or R10'; R8 is hydrogen, 1-6C alkyl which may be substituted, or saturated aliphatic heterocycle; R9 is hydrogen, 1-6C alkyl, 1-6C alkoxy or the like; R10 and R10' are each 3-8C cycloalkyl, aryl-1-6C alkyl or the like].
KOMIYA MASABUMI
TOZAKI SHINYA
ISOBE YOSHIAKI
Mayumi Matsuo
Horikawa Tamaki
Yuki Ito
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