NONREVERSIBLE DOPAMINE-BETA-HYDROXYLASE INHIBITOR

Title:

NONREVERSIBLE DOPAMINE-BETA-HYDROXYLASE INHIBITOR

Document Type and Number:

Japanese Patent JPS6322049

Kind Code:

A

Abstract:

Substituted beta -ethenyl and beta -ethynyl benzeneethanamine compounds of structrue (I) in which X is hydrogen or hydroxy; and R is ethenyl or ethynyl; are potent, irreversible inhibitors of mammalian dopamine- beta -hydroxylase. Included are pharmaceutical compositions and methods for using these compounds to inhibit DH, and processes and intermediates used in preparing active compounds.

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Inventors:

PAMERA AN CHIYANBAASU
ROURENSU AIBAN KURUSU

Application Number:

JP15426187A

Publication Date:

January 29, 1988

Filing Date:

June 18, 1987

Export Citation:

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Assignee:

SMITHKLINE BECKMAN CORP

International Classes:

A61K31/135; A61P9/12; A61P43/00; C07C51/00; C07C57/42; C07C59/68; C07C67/00; C07C209/00; C07C209/62; C07C211/27; C07C213/00; C07C215/52; C07C239/00; C07C271/08; C07F7/08; C12N9/99; (IPC1-7): A61K31/135; C07C57/42; C07C87/28; C07C91/30; C07C125/065; C07F7/08; C12N9/99

Attorney, Agent or Firm:

Aoyama

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