Title:
NOVEL 11BETAASUBSTITUTED 1*3*5*10**TRIENESTEROID PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JPS5390254
Kind Code:
A
Abstract:
Novel 11 beta -substituted- DELTA 1,3,5(10)-estratrienes of the formula I wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and heterocycle with at least one sulfur or oxygen heteroatom, R2 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 9 carbon atoms, R3 is selected from the group consisting of hydrogen, hydroxy, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms and R4 is selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 8 carbon atoms, acyloxy of an organic carboxylic acid of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms, with the proviso that R1 is not allyl when Z is hydrogen, R2 is methyl, R3 is hydroxy and R4 is hydrogen having estrogenic activity and their preparation.
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Inventors:
JIYAN JIYORUJIYU TOICHI
DANIERU FUIRIBEERU
DANIERU FUIRIBEERU
Application Number:
JP206778A
Publication Date:
August 08, 1978
Filing Date:
January 13, 1978
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/565; A61K31/58; C07J1/00; C07J7/00; C07J21/00; C07J31/00; C07J33/00; C07J51/00; C07J71/00; (IPC1-7): A61K31/565; C07J1/00