NEW MATERIAL:An anthracyclinon compound shown by the formula I (R1 is H, lower alkanoyl, or lower alkyl; R2 is O, or group consisting of H and OH simultaneously).
EXAMPLE: 9-Ethyl-2,6,7,9-tetrahydroxy-7,8-dihydronaphthacene-5,10,12(9H)-trione.
USE: An intermediate for synthesizing various amino sugar glucoside useful as carcinostatic agents.
PREPARATION: For example, a compound shown by the formula II is reacted with a compound shown by the formula III to give a compound shown by the formula IV, which is reduced with a hydride complex to give a compound shown by the formula V, which is further catalytically reduced to give a compound shown by the formula VI, which is then dehydrated, oxidized to give a compound shown by the formula VII, which is selectively acylated or alkylated, to give a compound shown by the formula I -1b where R2 is O.
| JPS58124735 | TETRAHYDROXYANTHRAQUINONE DERIVATIVE |
| WO/2002/076916 | SELF-REDUCING ANTHRAQUINONE COMPOUNDS |
| JPS5323960 | PREPARATION OF DIPHENOXYANTHAQUINONES |
YOSHIOKA TAKEO
YOSHIMOTO AKIHIRO
SHIMAUCHI YASUTAKA
ISHIKURA TOMOYUKI
SAWA TSUTOMU
TAKEUCHI TOMIO
UMEZAWA HAMAO
