NOVEL ANTIVIRAL AGENT AGAINST HBV INFECTION

Japanese Patent JP2019034943

A

To provide a novel compound useful as a pregenomic RNA capsid formation inhibitor useful for the treatment of hepatitis B virus (HBV) infection and related disease states.SOLUTION: The compound is, for example, a compound represented by formula (XXII) or formula (XXIV), or an enantiomer, diastereomer, pharmaceutically acceptable salt, hydrate or solvate thereof.SELECTED DRAWING: None

XU XIAODONG
GUO JU-TAO
TONG XIAO
DU YANMING
TIMOTHY BLOCK
SIMON DAVID PETER BAUGH
YE HONG

JP2018177094A

March 07, 2019

September 21, 2018

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UNIV DREXEL
BARUCH S BLUMBERG INST
ARBUTUS BIOPHARMA INC

C07C233/66; A61K31/167; A61K31/18; A61K31/22; A61K31/337; A61K31/351; A61K31/357; A61K31/396; A61K31/397; A61K31/40; A61K31/415; A61K31/42; A61K31/421; A61K31/423; A61K31/426; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4412; A61K31/4453; A61K31/4465; A61K31/4468; A61K31/47; A61K31/472; A61K31/505; A61K31/5375; A61K31/55; A61K31/63; A61P1/16; A61P31/14; A61P35/00; C07C311/43; C07D203/26; C07D205/04; C07D207/06; C07D211/96; C07D213/40; C07D213/42; C07D213/75; C07D215/38; C07D217/24; C07D223/06; C07D231/40; C07D239/26; C07D261/14; C07D263/48; C07D263/58; C07D277/46; C07D295/30; C07D305/08; C07D309/04; C07D319/18

JP6409001B2	2018-10-17
JP5977347B2	2016-08-24

WO2010123139A1

2010-10-28

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Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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