NEW MATERIAL:A compound expressed by formula I or salt of said compound [R1 to R3 are H, halogen, 1-3C alkyl, 1-3C alkoxy or amino, etc.; R4 and R5 are H, 1-3C alkyl or cyano, etc.; R6 is H, 1-3C alkyl or benzyl; X is single bond, -CHR7-CHR8-(CHR9)m- or -S(O)n-CHR8-(CHR9)m-, etc., (R7 to R9 are H, 1-3C alkyl, cyano or carboxy, etc.; m is 0 or 1; n is 0-2)].
EXAMPLE: 1-bromo-2,3,4,5-tetrahydro-1H-benzazepine-9-carboxylic acid.
USE: Useful for remedy of rheumatoid arthritis having immunomodulating action and introducing ability of strong suppressor T-cell.
PREPARATION: A compound expressed by formula II is treated with alkali and reacted using oxidizing agent (e.g. aqueous hydrogen peroxide) at 0-50°C for 30min to 3hr to afford the compound expressed by formula I.
KONO YASUSHI
KOJIMA EISUKE
SAITO KOJI
