Title:
NOVEL D-HOMOSTEROID
Document Type and Number:
Japanese Patent JPS59148800
Kind Code:
A
Abstract:
The novel D-homosteroids of the formula I wherein R1 represents a -CN, =NOH or =CH-NHOH group; R2 represents oxo or, where R1 represents a -CN group, R2 represents oxo or a -OAc group; or R1 and R2 together with carbon atoms 2 and 3 of the steroid skeleton represents a [2,3-d]-fused isoxazole ring, a [3,2-c]-fused pyrazole ring, a [3,2-c]-fused N-acylated pyrazole ring or a [2,3-c]-fused furazan ring; Ac represents an acyl group; R3 and R4 represent methyl and R5 and R6 together represent an additional bond between carbon atoms 5 and 6 of the steroid skeleton; or R4 and R5 together represent -O-, R3 represents hydrogen or methyl, and R6 represents hydrogen; R7 represents hydrogen, lower-alkyl or ethynyl; R8 represents hydroxy or acyloxy; or R7 and R8 together represent a spiroether group of the formula 17a or a spirolactone group of the formula 17a the dotted 16,17-bond is an optional additional carbon-carbon bond; and the dotted 2,3-bond is an additional carbon-carbon bond when R1 and R2 together with carbon atoms 2 and 3 form the isoxazole or pyrazole ring or when R2 represents a -OAc group, inhibit the synthesis of progesterone in organisms and can be used for fertility control. The novel D-homosteroids can be manufactured by molecular modifications of other D-homosteroids.
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Inventors:
ANDORU FUYURUSUTO
MARUSERU MIYURAA
URURITSUHI KERUPU
RUDORUFU BIIHIERUTO
MARUSERU MIYURAA
URURITSUHI KERUPU
RUDORUFU BIIHIERUTO
Application Number:
JP2012884A
Publication Date:
August 25, 1984
Filing Date:
February 08, 1984
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/15; A61K31/275; C07J63/00; C07J71/00; (IPC1-7): A61K31/15; A61K31/275; A61K31/34; A61K31/41; A61K31/415; A61K31/42; C07J63/00; C07J71/00
Attorney, Agent or Firm:
Heiyoshi Odashima