Title:
NOVEL FLUORESCENT COMPOUND, AND LIPID BILAYER DYEING METHOD AND ENDOCYTOSIS DETECTION METHOD USING SAID COMPOUND
Document Type and Number:
Japanese Patent JP2022038779
Kind Code:
A
Abstract:
To provide a fluorescent compound which has high retention in a lipid bilayer, has excellent ease of handling, and can achieve uniform dyeing in a dyeing target; and a lipid bilayer dyeing method and an endocytosis detection method using said compound.SOLUTION: Disclosed is a fluorescent compound represented by general formula (I), (I)', or (I)": Ch-L-A-H (I), (Ch-L-A-)nXn+ (I)' and Ch-LH+-A-(I)", Ch is a hydrophobic-field-sensitive fluorescent chromophore in which the fluorescence intensity increases in hydrophobic environments; A-H is an anionic functional group capable of generating anions by deprotonation; Xn+ is a positive ion having biological compatibility; n is 1, 2, or 3; L is a linker that binds to a hydrophobic-field-sensitive fluorescent chromophore and links the fluorescent chromophore and the anionic functional group; and LH+ indicates a state where the linker, which contains a cationic functional group capable of generating cations by protonation, has generated a cation by protonation.SELECTED DRAWING: Figure 1
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Inventors:
TAKAHASHI MASATAKA
KIYONO RYO
EZOE TAKATOSHI
ISHIYAMA MUNETAKA
KIYONO RYO
EZOE TAKATOSHI
ISHIYAMA MUNETAKA
Application Number:
JP2020143432A
Publication Date:
March 10, 2022
Filing Date:
August 27, 2020
Export Citation:
Assignee:
DOJINDO LABORATORIES
International Classes:
G01N33/48; C09B5/62; C09B57/08; C09K11/06; G01N33/58
Attorney, Agent or Firm:
Kazuaki Nakajima
Previous Patent: JPWO2022038778
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