NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF

Title:

NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF

Document Type and Number:

Japanese Patent JP2015205910

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide prodrugs of stereodefined oligonucleotides to impart additional stability to oligonucleotide molecules in many in-vitro and in-vivo applications.SOLUTION: A nucleic acid prodrug has a structure represented by the formula (1), where each instance of Ba is independently a blocked or unblocked adenine, cytosine, guanine, thymine, uracil or modified nucleobase.

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Inventors:

GREGORY L VERDINE
MEENA MEENA
IWAMOTO NAOKI

Application Number:

JP2015133754A

Publication Date:

November 19, 2015

Filing Date:

July 02, 2015

Export Citation:

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Assignee:

ONTORII INC

International Classes:

A61K31/7125; A61P1/18; A61P3/02; A61P35/00; A61P43/00; C07H19/10

Foreign References:

US20070149462A1	2007-06-28
WO1997047637A1	1997-12-18
WO1996007392A2	1996-03-14

Other References:

BIOORGANIC CHEMISTRY, vol. 23(1), JPN6014030639, 1995, pages 1 - 21
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4(20), JPN6014030641, 1994, pages 2471 - 2476
OKA, NATSUHISA ET AL.: "Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approac", ORGANIC LETTERS, vol. 11, no. 4, JPN6017009049, 21 January 2009 (2009-01-21), pages 967 - 970, XP055179581, DOI: doi:10.1021/ol802910k

Attorney, Agent or Firm:

Takayuki Hirose

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