Title:
PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS
Document Type and Number:
Japanese Patent JP2015205911
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds with protein kinase inhibitory activity effective, e.g., in treating kinase related disorders, particularly cancer, and pharmaceutical compositions comprising the compounds.SOLUTION: There is provided a heterocyclic compound having a pyrimido-diazepinone scaffold represented by formula A. (X is CHR4, CR4, NH, NR4 or N; Y is NR5, N, S, SO, SO2, O, CHR5 or CR5; at least one of X and Y is NH, NR4, NR5, N, S, SO, SO2 or O; and A and B are each independently a single bond or a double bond.)
Inventors:
NATHANAEL S GRAY
DENG XIANMING
NICHOLAS PAUL KWIATKOWSKI
DENG XIANMING
NICHOLAS PAUL KWIATKOWSKI
Application Number:
JP2015134522A
Publication Date:
November 19, 2015
Filing Date:
July 03, 2015
Export Citation:
Assignee:
DANA FARBER CANCER INST INC
International Classes:
C07D471/14; A61K31/551; A61K31/5513; A61K31/553; A61K31/554; A61K45/00; A61P1/04; A61P1/16; A61P7/00; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P25/02; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/16; A61P31/18; A61P31/22; A61P33/06; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P43/00; C07D487/04; C07D487/14; C07D495/14; C07D498/04; C07D513/04
Domestic Patent References:
| JP5908728B2 | 2016-04-26 |
Foreign References:
| WO2009067547A1 | 2009-05-28 | |||
| WO2007079826A1 | 2007-07-19 | |||
| WO2004076454A1 | 2004-09-10 | |||
| WO1999061444A2 | 1999-12-02 | |||
| WO2008003958A2 | 2008-01-10 | |||
| WO2007095188A2 | 2007-08-23 | |||
| WO2008113711A1 | 2008-09-25 | |||
| WO2009067547A1 | 2009-05-28 | |||
| WO2007079826A1 | 2007-07-19 | |||
| WO2004076454A1 | 2004-09-10 | |||
| WO1999061444A2 | 1999-12-02 |
Attorney, Agent or Firm:
Norio Saeki
Previous Patent: NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF
Next Patent: HIGH PERMEABILITY COMPOSITION AND APPLICATION THEREOF
Next Patent: HIGH PERMEABILITY COMPOSITION AND APPLICATION THEREOF