Title:
NOVEL VACCINE AGAINST MULTIPLE SUBTYPES OF INFLUENZA VIRUS
Document Type and Number:
Japanese Patent JP2013247962
Kind Code:
A
Abstract:
To provide a DNA plasmid capable of expressing a consensus influenza antigen in a cell of a mammal.
A plasmid comprises: an encoding sequence comprising consensus hemagglutinin (HA), neuraminidase (NA), M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof; a promoter operably linked to the encoding sequence that regulates expression of the consensus influenza antigen. In one aspect, the DNA plasmid further comprises an IgG leader sequence attached to an N-terminal end of the encoding sequence and operably linked to the promoter.
Inventors:
DRAGHIA-AKLI RUXANDRA
WEINER DAVID B
YAN JIAN
LADDY DOMINICK
WEINER DAVID B
YAN JIAN
LADDY DOMINICK
Application Number:
JP2013182786A
Publication Date:
December 12, 2013
Filing Date:
September 04, 2013
Export Citation:
Assignee:
UNIV PENNSYLVANIA
VGX PHARMACEUTICALS LLC
VGX PHARMACEUTICALS LLC
International Classes:
C12N15/09; A61K31/713; A61K39/00; A61K39/145; A61P31/16; C12N15/117
Domestic Patent References:
| JP2011506272A | 2011-03-03 |
Foreign References:
| WO2005116270A2 | 2005-12-08 | |||
| WO2007011904A2 | 2007-01-25 |
Other References:
D.J.LADDY, ET AL., VACCINE, JAN.2007, 25, PP2984-2989, JPN7013000843, ISSN: 0002952281
DATABASE UNIPROT[ONLINE] ACCESSION NO: Q1AQW8，[RETRIEVED ON 17 AUG 2015] ＵＲＬ，HTTP://WWW.UNIPROT, JPN7015002424, ISSN: 0003148179
DATABASE UNIPROT[ONLINE] ACCESSION NO: Q1WP97，[RETRIEVED ON 17 AUG 2015] ＵＲＬ，HTTP://WWW.UNIPROT, JPN7015002425, ISSN: 0003148180
DATABASE UNIPROT[ONLINE] ACCESSION NO: Q1AQW8，[RETRIEVED ON 17 AUG 2015] ＵＲＬ，HTTP://WWW.UNIPROT, JPN7015002424, ISSN: 0003148179
DATABASE UNIPROT[ONLINE] ACCESSION NO: Q1WP97，[RETRIEVED ON 17 AUG 2015] ＵＲＬ，HTTP://WWW.UNIPROT, JPN7015002425, ISSN: 0003148180
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita