Title:
免疫賦活活性を有する核酸誘導体
Document Type and Number:
Japanese Patent JP6611298
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide, as a nucleic acid derivative having an immunostimulatory activity, a double-stranded oligonucleotide containing a CpG oligonucleotide as mentioned below. An adjuvant comprising a double-stranded oligonucleotide in which a first strand is a CpG oligonucleotide composed of 8 to 50 nucleotides and a second strand is an oligonucleotide composed of 8 to 60 nucleotides and containing a sequence capable of hybridizing with the first strand, wherein a lipid is bonded to the second strand with a linker interposed therebetween.
Inventors:
Kei Nagimiya
Tetsuya Tanino
Mitsuaki Sekiguchi
Yasunori Mioka
Noriichi Kuroda
Atsushi Nakamura
Tetsuya Tanino
Mitsuaki Sekiguchi
Yasunori Mioka
Noriichi Kuroda
Atsushi Nakamura
Application Number:
JP2019508453A
Publication Date:
November 27, 2019
Filing Date:
March 29, 2017
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
A61K39/39; A61P31/00; A61P35/00
Domestic Patent References:
| JP2012500827A | ||||
| JP2015514108A | ||||
| JP2005526497A | ||||
| JP2015131852A | ||||
| JP2014012009A |
Foreign References:
| WO2015105083A1 | ||||
| WO2001012804A2 |
Other References:
Nature, 2014, Vol.507, pp.519-522
BMB reports, 2010, Vol.43, No.3, pp164-169
PLOS ONE, 2014, Vol.9, No.4, e94596
European J. Pharmaceutical Sciences, 2012, Vol.47, pp.352-358
BMB reports, 2010, Vol.43, No.3, pp164-169
PLOS ONE, 2014, Vol.9, No.4, e94596
European J. Pharmaceutical Sciences, 2012, Vol.47, pp.352-358
Attorney, Agent or Firm:
Kenichi Sugita
Hideaki Watanabe
Hideaki Watanabe