Title:
OLIGONUCLEOTIDE ADJUSTMENT OF CELL ADHESION
Document Type and Number:
Japanese Patent JP2948541
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new oligo-nucleic acid targeting a coding domain, 3'- and 5'-untranslation domains or an intron/exon binding site of an mRNA coding for an endothelial leukocyte adhesive molecule-1 and inhibiting manifestation of an intercellular adhesive protein.
SOLUTION: This oligonucleotide is an anti-sense oligonucleotide targeting a coding domain, 3'- and 5'-untranslation domains or an intron/exon binding site of a messenger RNA coding for an endothelial leukocyte adhesive molecule-1, capable of adjusting manifestation of the endothelial leukocyte adhesive molecule-1, is a new oligonucleotide containing a base sequence of formula I to formula VII, is capable of inhibiting functions of a nucleic acid coding for an intercellular adhesive protein and is useful for treating asthma, rheumatic arthritis, graft rejection, inflammatory enteric disease, psoriasis, etc. The oligonucleotide is obtained by screening an anti-sense chain of the endothelial leukocyte adhesive molecule-1 by its manifestation inhibition test.
Inventors:
BENETSUTO SHII FURANKU
MIRABERI KURISUTOFUAA KEI
MIRABERI KURISUTOFUAA KEI
Application Number:
JP30224096A
Publication Date:
September 13, 1999
Filing Date:
November 13, 1996
Export Citation:
Assignee:
AISHISU PHARM INC
International Classes:
A61K31/00; A61K31/70; A61K31/7088; C12N15/09; A61P17/00; A61P17/06; A61P25/04; A61P29/00; A61P35/00; A61P35/04; C07H21/02; C07H21/04; C07K14/705; C12N15/113; C12Q1/68; A61K38/00; A61K48/00; (IPC1-7): C12N15/09; A61K31/00; C07H21/02; C07H21/04; C12Q1/68
Domestic Patent References:
| JP4502859A |
Other References:
【文献】国際公開92/3139(WO,A1)
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)