ONCOLYTIC MODIFIED ADENOVIRUSES, MODIFIED VIRUSES FOR TREATING DISEASE, AND VIRAL FORMULATIONS CONTAINING THESE

Title:

ONCOLYTIC MODIFIED ADENOVIRUSES, MODIFIED VIRUSES FOR TREATING DISEASE, AND VIRAL FORMULATIONS CONTAINING THESE

Document Type and Number:

Japanese Patent JP2016160249

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide modified viruses for treating diseases that selectively exert cell-killing activity on diseases associated with cancer cells or the cells accelerating stabilization of ARE-mRNA, such as osteoporosis, rheumatism, viral disease and inflammatory disease.SOLUTION: The invention provides an antitumor adenovirus formulation (described as dl355 in Fig. 1) containing a modified adenovirus with E4orf6 encoding an E4orf6 protein in which C-terminal region is deleted or a modified E4orf6 protein consisting of an amino acid sequence represented by a particular sequence.SELECTED DRAWING: Figure 1

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Inventors:

TONO FUMIHIRO

Application Number:

JP2015043345A

Publication Date:

September 05, 2016

Filing Date:

March 05, 2015

Export Citation:

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Assignee:

UNIV HOKKAIDO

International Classes:

A61K35/761; A61K31/7088; A61K48/00; A61P19/10; A61P29/00; A61P31/12; A61P31/14; A61P31/16; A61P31/20; A61P31/22; A61P35/00

Attorney, Agent or Firm:

Akio Ichiiri
Maki Kaneko

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