OXAMIC ACID AND ITS DERIVATIVE AS THYROID RECEPTOR LIGAND

Japanese Patent JP2005162759

A

To provide a new oxamic acid and its derivative which are useful for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary artery disease, hypercholesterolemia, depression and osteoporosis.

The compound is one represented by formula (1), its prodrug, its geometric or optical isomer or a pharmaceutically acceptable salt of the compound, the prodrug or the isomer.

JP2001518499	INDUSTRIAL APPLICABILITY The use of D-methionine to reduce the toxicity of ototoxic agents, noise and radiation.
JP2003530357	INDUSTRIAL APPLICABILITY Treatment of fungal infections with a polyene or β-glucan synthase inhibitor antifungal agent in combination with an anti-hsp antibody.

CHIANG YUAN-CHING PHOEBE
DOW ROBERT LEE

JP2004352241A

June 23, 2005

December 06, 2004

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PFIZER PROD INC

A61K31/10; A61K31/165; A61K31/167; A61K31/18; A61K31/198; A61K31/223; A61K31/36; A61K31/381; A61K31/40; A61K31/404; A61K31/445; A61K31/4453; A61K31/47; A61K31/472; A61K31/5375; A61K31/55; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/16; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P17/00; A61P19/10; A61P25/24; A61P27/06; A61P43/00; C07C233/56; C07C235/60; C07C235/74; C07C311/29; C07C317/22; C07C317/50; C07C323/41; C07D209/08; C07D209/32; C07D211/14; C07D211/16; C07D211/22; C07D215/08; C07D215/20; C07D217/04; C07D217/06; C07D217/08; C07D233/20; C07D295/096; C07D295/16; C07D295/08; C07D295/192; C07D295/22; C07D295/26; C07D317/54; C07D317/58; C07D317/68; C07D333/20; C07D333/22; C07D333/36; (IPC1-7): C07C233/56; A61K31/167; A61K31/18; A61K31/198; A61K31/223; A61K31/36; A61K31/381; A61K31/40; A61K31/404; A61K31/445; A61K31/4453; A61K31/47; A61K31/472; A61K31/5375; A61K31/55; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P17/00; A61P19/10; A61P25/24; A61P27/06; A61P43/00; C07C235/60; C07C311/29; C07C317/22; C07D209/08; C07D209/32; C07D211/16; C07D211/22; C07D215/08; C07D217/04; C07D217/06; C07D217/08; C07D233/20; C07D295/08; C07D295/16; C07D295/22; C07D317/54; C07D317/68; C07D333/22; C07D333/36

Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji

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