Title:
オキシム化合物およびその使用
Document Type and Number:
Japanese Patent JP5539717
Kind Code:
B2
Abstract:
The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Inventors:
Akira Matsumura
Hidenori Mikamiyama
Maki Tsuno
Donald Jay Kyle
Bin Xiao
Chang Chao Yao
Hidenori Mikamiyama
Maki Tsuno
Donald Jay Kyle
Bin Xiao
Chang Chao Yao
Application Number:
JP2009519515A
Publication Date:
July 02, 2014
Filing Date:
July 12, 2007
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
PURDUE PHARMA L.P.
PURDUE PHARMA L.P.
International Classes:
C07D211/72; A61K31/423; A61K31/4468; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/506; A61K31/5377; A61P9/06; A61P9/10; A61P9/12; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D211/96; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D471/04; G01N33/15; G01N33/50; C12N15/09
Domestic Patent References:
| JP2003519150A | ||||
| JP2002518500A | ||||
| JP2001522851A | ||||
| JP2009525961A | ||||
| JP2003529584A | ||||
| JP2004517890A | ||||
| JP2003535094A | ||||
| JP2001522832A | ||||
| JP2004525132A | ||||
| JP2008530252A |
Foreign References:
| WO2005014543A1 | ||||
| WO2005080372A1 | ||||
| WO2004026833A1 | ||||
| WO1998039325A1 | ||||
| WO2005048933A1 | ||||
| WO2005018551A1 |
Other References:
J.Med.Chem.,(1988),31(4),p.875-885
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STN ON THE WEB, FILE REGISTRY, RN=852801-26-4,852799-46-3,849996-86-7,847434-06-4,847433-43-6,777041-45-9,753433-58-8,749192-10-7,736913-81-8,702634-43-3,686253-90-7,487009-24-5,477847-29-3,477847-28-2,404912-43-2,404912-42-1,329782-70-9,329782-69-6,327990-42-1,317374-83-7,317374-82-6,300803-89-8,46989-79-1,445392-83-6
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe