Title:
【発明の名称】移動する荷電コロイド状粒子の表面を利用した動電学的分離方法と装置
Document Type and Number:
Japanese Patent JP2799709
Kind Code:
B2
Abstract:
An electrokinetic method for separating molecular species employs the surface of moving charged colloidal particles in a buffered dispersing medium, in a process which combines electrophoresis and a variant of chromatography in which the "stationary phase" surface moves. The colloidal particles have on their surface a material having the ability to interact selectively with the molecular species to be separated. The surface of the particles as originally formed may have such an ability, or the surface is modified to produce it. In one embodiment the colloidal particles are negatively charged and the surface-modifying materials are metal ions. In another embodiment the surface of the colloidal particles is modified by the incorporation of affinity groups. The analytes distribute themselves between the dispersing medium and the surface of the colloidal particles, resulting in analyte migration rates which are functions of the individual distribution equilibrium constants and the rate of colloidal particle migration. A capillary column for conducting the method includes surface-modified charged colloidal particles in a buffered dispersing medium.
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Inventors:
Barry El Carger
Aaron Cohen
Aaron Cohen
Application Number:
JP7084488A
Publication Date:
September 21, 1998
Filing Date:
March 24, 1988
Export Citation:
Assignee:
Northeastern University
International Classes:
B01D15/08; B01D57/02; B01D61/42; G01N27/447; C25B7/00; G01N30/58; G01N30/02; G01N30/28; (IPC1-7): G01N27/447; B01D57/02; B01D61/42; C25B7/00
Domestic Patent References:
| JP6283643A |
Other References:
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Attorney, Agent or Firm:
Akimoto Teruo