Title:
【発明の名称】生体内分解性標的指向性マイクロパーティクル送達システム
Document Type and Number:
Japanese Patent JP3242118
Kind Code:
B2
Abstract:
Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligands are described. The copolymers are polyesters composed of alpha-hydroxy acid subunits such as D,L-lactide and pseudo-alpha-amino acid subunits which may be derived from serine or terpolymers of D,L-lactide and glycolide and pseudo-alpha-amino acid subunits which may be derived from serine. Stable vaccine preparations useful as delayed release formulations containing antigen or antigens and adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody and protective responses.
Inventors:
Sokol, Kenneth, Kee.
Chung, Pele
Klein, Michael, H.
Chung, Pele
Klein, Michael, H.
Application Number:
JP52816998A
Publication Date:
December 25, 2001
Filing Date:
December 19, 1997
Export Citation:
Assignee:
Connaught Laboratories Limited
International Classes:
A61K9/16; A61K9/50; A61K39/39; A61K47/34; C08G63/685; C08G63/688; A61K9/48; C08G63/78; C08G75/26; C08J3/14; C08J5/18; C08K5/00; C08L101/16; A61K9/00; (IPC1-7): C08G63/685; C08G75/26; C08J3/14; C08J5/18
Other References:
【文献】欧州特許出願公開600161(EP,A1)
Attorney, Agent or Firm:
Nobuyuki Kaneda (2 others)