PEPTIDE ALKYLAMIDE, MANUFACTURE AND MEDICINE

Title:

PEPTIDE ALKYLAMIDE, MANUFACTURE AND MEDICINE

Document Type and Number:

Japanese Patent JPS5978150

Kind Code:

A

Abstract:

This invention relates to biologically active tripeptide and tetrapeptide alkylamides of the general formula wherein R1 is an alkyl with 1 to 5 carbon atoms, A is a peptidically bound alanine or proline residue, B is a peptidically bound glycine, alanine or proline residue, n is an integer of 1 or 2, and R2 is an alkylcarbonylamino group with 2 to 12 carbon atoms, an alkenyl with 6 to 12 carbon atoms or a benzyloxycarbonylamino group. The compounds effectively inhibit the enzymatic activity of pancreatic and leucocytal elastase and are expected to find use in the treatment of acute pancreatitis, chronic obstructive pulmonary disease, pulmonary emphysema, and certain forms of arthritis. The invention also relates to processes for the preparation of the title compounds and to pharmaceutical compositions containing them.

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Inventors:

EFUSHIEN KASAFUIREKU
PUREMISURU FURICHI
IYAN SURABII
ARENA ROUBAROBA

Application Number:

JP17438683A

Publication Date:

May 04, 1984

Filing Date:

September 22, 1983

Export Citation:

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Assignee:

SPOFA SPOJENE PODNIKY

International Classes:

A61K38/55; A61P1/00; A61P11/00; C07K5/08; A61P29/00; C07K1/06; C07K1/113; C07K5/083; C07K5/10; C07K5/113; C07K14/81; (IPC1-7): A61K37/02; A61K37/64; C07C103/52

Attorney, Agent or Firm:

Aoki Akira

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