Title:
グルコース代謝を制御するためのペプチジルペプチダーゼIV阻害剤
Document Type and Number:
Japanese Patent JP4781347
Kind Code:
B2
Abstract:
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the P1 and/or P2 position of the inhibitor that contain a carboxylic acid moiety. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
Inventors:
Bachofutin, William W
Rye, Hun-Sen
Wu, Wengen
Rye, Hun-Sen
Wu, Wengen
Application Number:
JP2007501012A
Publication Date:
September 28, 2011
Filing Date:
February 23, 2005
Export Citation:
Assignee:
TRUSTEES OF TUFTS COLLEGE
International Classes:
C07F5/02; A61K31/155; A61K31/195; A61K31/198; A61K31/4164; A61K31/69; A61K38/04; A61K38/06; A61K38/08; A61K38/28; A61K45/00; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P5/00; A61P43/00; C07K5/06; C07K7/06
Domestic Patent References:
| JP10510245A |
Foreign References:
| WO2003045977A2 | 2003-06-05 |
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma