PERFLUOROALKYL-SUBSTITUTED BENZOLYGUANIDINES, THEIR PREPARATION, THEIR USE AS MEDICAMENT OR DIAGNOSTIC AGENT, AND MEDICAMENT CONTAINING THE SAME

Japanese Patent JP3802582

B2

PURPOSE: To obtain the subject new compounds extremely suitable as an antiarrhythmic formulation having a cardioprotective component for prevention of infarction, treatment of infarction and treatment of angina pectoris. CONSTITUTION: The compound of formula I [R(1) is R(6)-SOm {R(6) is a 1-6C perfluoroalkyl; (m) is 0-2}; R(2) and R(3) are each H, a halogen, a 1-4C alkyl, a 1-4C alkoxy, a substitutable phenoxy or a substitutable 1-, 2- or 3-pyrolyl; R(4) and R(5) are each H, a 1-3C alkyl, a halogen, CN, OR(7), NR(8)R(9) {R(7) to R(9) are each H or a 1-4C alkyl} or -(CH2)n-(CF2)o-CF3 {(n) is 0 or 1; (o) is 0-2}] or its salt, e.g. 4-(4-fluorophenoxy)-3- trifluoromethylsulfonylbenzoylguanidine. The compound is obtained by reacting a compound of formula II (L is a leaving group) with guanidine and is suitable for preparing a chemical tool for an inhibitor of Na+/H+ exchanger in a diagnosis of hypertension and productive disease.