Title:
カンプトテシン類高分子誘導体を含有する医薬組成物
Document Type and Number:
Japanese Patent JP6735759
Kind Code:
B2
Abstract:
Provided is a pharmaceutical preparation including a polymerized camptothecin derivative that is obtained by bonding a camptothecin derivative having nanoparticle-forming properties by associating in an aqueous solution, to a polymer carrier, the pharmaceutical preparation composition having enhanced preparation stability. Particularly, a pharmaceutical preparation maintaining nanoparticle-forming properties and camptothecin derivative bonding stability, which are important factors, and having excellent storage stability is provided. Disclosed is a pharmaceutical preparation including a block copolymer in which a polyethylene glycol segment is linked to a polyglutamic acid segment including a glutamic acid unit having a camptothecin derivative bonded thereto; and a saccharide. The pharmaceutical preparation forms associates in an aqueous solution, and the ratio of change in the scattered light intensity of the associates of the pharmaceutical preparation obtained after the pharmaceutical preparation is stored for 4 weeks at 40°C under light-shielded conditions, is 20% or less.
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Inventors:
Susumu Aoki
Shinya Fujita
Shinya Fujita
Application Number:
JP2017537793A
Publication Date:
August 05, 2020
Filing Date:
August 25, 2016
Export Citation:
Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA
International Classes:
A61K47/64; A61K9/19; A61K31/4745; A61K47/26; A61P35/00
Foreign References:
| WO2011049042A1 |
Other References:
Cancer Res.,2006年10月15日,66(20),p.10048-10056
Attorney, Agent or Firm:
Kawaguchi International Patent Office